ClarityAccessHub

What ClarityAccessHub Does

The operating infrastructure for anti-amyloid therapy.

ClarityAccessHub is the patient access network purpose-built for anti-amyloid therapy delivery. The Memory Rx Toolkit operationalizes the therapy readiness, site-of-care, monitoring, and registry workflow that anti-amyloid therapy requires. CerebraLinked is the technology platform inside the toolkit that runs the four-pillar workflow.

The Model

Patient access for anti-amyloid therapy. Built around AD workflow specifically.

What we deliver to members

  • AD-specific coordination economics. Manufacturer-funded payments for the patient-access and coordination work anti-amyloid therapy delivery requires — built around the actual workflow AD infusion centers operate.
  • The Memory Rx Toolkit. CerebraLinked and the four-pillar workflow. ARIA surveillance, biomarker qualification, registry submission, payer coordination — operationalized for AD.
  • Patient access. Qualified AD patients routed to credentialed delivery sites. The AD channel made to work — for the patient, the practice, and the manufacturer.
Free to join. ClarityAccessHub is funded by arms-length manufacturer service and data agreements. Member sites capture coordination payments and infrastructure value without writing ClarityAccessHub a check.

Why purpose-built for AD

Anti-amyloid therapy isn't a typical specialty infusion drug. The qualification workflow, the ARIA monitoring obligations, the registry requirements, and the coordination across multiple stakeholders are AD-specific. A generic hub or purchasing model doesn't operationalize these. ClarityAccessHub is purpose-built around them.

  • Referring neurologist or memory specialist. Diagnosis, cognitive testing, qualification
  • Biomarker capability. Plasma p-tau217, CSF or PET confirmation, APOE genotyping
  • Imaging center. Baseline MRI and ARIA surveillance MRIs throughout treatment
  • Credentialed AIC. Anti-amyloid administration, real-time monitoring, REMS compliance
  • Payer layer. Prior authorization, CMS NCD registry, claim adjudication
  • Caregiver support. Adherence, transportation, AE reporting, decision support

If any link in the AD chain fails, the patient doesn't get treated. ClarityAccessHub operates the infrastructure that holds the AD chain together.

ClarityAccessHub is designed to complement neurologist-directed care pathways and existing physician networks by supporting the downstream therapy readiness, site-of-care, monitoring, and operational coordination layers required for anti-amyloid therapy. We don't replace the referring neurologist — we extend their reach.

The Memory Rx Toolkit · Powered by CerebraLinked

One technology platform. Four AD pillars. The full AD registry layer.

ClarityAccessHub is the parent access network. The Memory Rx Toolkit is the AD-specific operational implementation. CerebraLinked is the technology platform inside the toolkit that operationalizes the four-pillar workflow anti-amyloid therapy requires.

Manufacturers
Service contracts and data agreements with brand manufacturers
Referring Sources
Memory specialists, neurology practices, primary care
ClarityAccessHub · Memory Rx Toolkit

CerebraLinked — Four Pillars + Full Registry Layer

1Diagnosis
Referral routing, qualification triage, intake protocols
2Therapy Readiness Coordination
Post-diagnosis biomarker workflow, ARIA risk stratification, APOE testing
3Site-of-Care Coordination
Credentialed infusion site matching, fulfillment, scheduling
4Payer Layer
PA, CMS NCD compliance, denial management, claims
REGISTRIES & DATA · CMS NCD patient registry · AlzNet · ALZ-910 · longitudinal real-world evidence
Member Network
National infusion center network · Specialty neurology coverage · WeInfuse-integrated workflow

What the Memory Rx Toolkit Delivers

Six AD-specific capabilities the Memory Rx Toolkit operationalizes.

The four-pillar workflow inside CerebraLinked is the operational engine. The Memory Rx Toolkit puts that engine to work on six AD-specific capabilities anti-amyloid manufacturers need at network scale.

01

AD Patient Identification at Prodromal & At-Risk Stage

Plasma biomarker screening at scale for AD — Aβ42/40, p-tau217, p-tau181, GFAP, NfL. APOE genotyping with appropriate counseling. Cognitive baseline assessment and longitudinal monitoring. Identifies candidates for current anti-amyloid therapy and the AD prevention-indication products coming behind it.

02

Site-of-Care Matching

Once a patient is therapy-ready, ClarityAccessHub routes them to the nearest credentialed infusion center with appropriate ARIA monitoring capability and payer credentialing. Geographic, capacity, and quality factors built into the matching.

03

Longitudinal At-Risk Patient Panels

Multi-year patient cohorts tracked through standardized assessment. Real-world evidence on disease progression, intervention response, and biomarker trajectories. Data assets that support label expansion, pricing justification, and pipeline planning.

04

AD Clinical Trial Site Infrastructure

Patient identification and enrollment for AD prevention-indication clinical trials. Standardized AD clinical workflow across network sites. Data quality and protocol adherence at network scale. Geographic and demographic diversity supporting AD trial regulatory submission.

05

Real-World Evidence & Post-Market Surveillance

Adverse event tracking, outcomes monitoring, comparative effectiveness research, and Health Economics and Outcomes Research support. The data infrastructure that increasingly determines payer coverage decisions, label expansions, and post-market commitments.

06

Patient Access & Adherence Programs

Patient navigation, financial assistance coordination, treatment adherence support, and family caregiver education. The wraparound services that determine real-world treatment success and adoption at scale.

Why Now

The science just made prevention operationally real.

Two convergent shifts make this the inflection point. Plasma biomarkers have crossed the operational threshold for population-scale screening. And the pipeline behind today's therapies is the deepest the neurodegenerative space has ever produced — a multi-year, multi-product opportunity the Memory Rx Toolkit is built to serve.

Plasma Biomarkers Have Arrived

p-tau217
Best-performing plasma marker for amyloid pathology. Rivals PET in recent studies. Now commercially available.
p-tau181
Established marker. Good correlation with CSF and PET. Widely used in research and clinical settings.
Aβ42/40 ratio
Earliest plasma signal. Useful for ruling out AD pathology. Lower specificity alone.
GFAP
Astrocyte activation marker. Adds prognostic value in combination panels.
NfL
Neurodegeneration marker. Non-specific to AD but useful for monitoring progression.
APOE genotype
Risk stratification. Now clinically meaningful with anti-amyloid ARIA risk profile by genotype.

Pipeline Catalysts 2026–2032

Anti-amyloid prevention
Major manufacturer pipelines targeting prodromal and preclinical AD. Trial infrastructure needed now.
Anti-tau therapies
Multiple sponsors in Phase 2/3. Tau pathology screening and longitudinal monitoring required.
GLP-1 cognitive prevention
Tirzepatide and semaglutide cardiovascular, kidney, and cognitive prevention indications expanding rapidly.
Combination therapies
Anti-amyloid + anti-tau + anti-inflammatory combinations require multi-modal delivery infrastructure.
Lewy body, PD, FTD
Pipeline expansion beyond AD. The infrastructure architecture serves broader neurodegenerative disease.
Cognitive trial enrollment
Industry-sponsored neurology trial enrollments doubled 2013–2023. Pipeline assets keep growing.

Purpose-built for AD therapy delivery.

ClarityAccessHub operationalizes the AD-specific infrastructure that anti-amyloid therapy requires — for the patients who need it, the clinicians who treat them, and the manufacturers who develop them.

Contact ClarityAccessHub